You can restart Mac using a keyboard shortcut if the mouse or trackpad is not responding. Press Control + Command + Power button (or Control + Command + Eject on older keyboards) at the same time. This command tells the system to restart immediately. When used, macOS will attempt to close running applications and reboot the computer. If any apps have unsaved work, the system may prompt you to save changes before restarting. Using a keyboard shortcut can be helpful when the screen becomes slow or partially unresponsive, allowing you to restart the Mac quickly without navigating through the Apple menu.